Only MALAT1 showed significant improvement in expression in severe human HF tissues (Fig. 7a), BDL-induced mouse HF tissues (Fig. 7b) and TGFβ1-induced JS-1 cells (Fig. 7c), with remarkable elevation of binding strengths and subcellular colocalization with DNMT1 (Fig. 7d–f). This evidence concerns the gene MALAT1 and hydrops fetalis.