RARA and acute promyelocytic leukemia: Aberrant binding of HDACs at specific promoter regions suppresses normal functional gene transcription, inducing malignancy, such as promyelocytic leukemia–retinoic acid receptor-α (PML–RARα) fusion proteins that reactivate HDACs and inhibit the expression of genes associated with hematopoietic cell differentiation, leading to the progression of acute promyelocytic leukemia (APL)70.