Additionally, verapamil treatment reduces tau phosphorylation at Ser202/Thr205 by blocking the TXNIP/p38 MAPK pathway and preventing Aβ-induced NLRP3 inflammasome activation and IL-1β secretion in the hippocampus of 5xFAD AD model mice63,68. This evidence concerns the gene NLRP3 and Alzheimer disease.