CD8A and cancer: Elevated LSD1 expression in breast, lung, and other cancer types is not only essential in maintaining CSC stemness and mediating chemoresistance143 but is also inversely proportional to the expression levels of T-cell-attracting chemokines (e.g., CXCL9 and CXCL10) and CD8+ T-cell infiltration, which predicts a poor prognosis in clinical practice144,145.