AKT1 and colorectal carcinoma: The depletion of PRMT6 results in increased p21, p27, and CD44 and downregulated MMP-9 expression and PI3K/AKT/mTOR signaling in CRPC, thus inducing sensitivity to chemotherapy, and the methylation of p21 by PRMT6 (R156) reduces chemosensitivity in CRC cells97,98.