EHMT2 and cancer: G9a (EHMT2/KMT1C), which is responsible for mono- and dimethylation of H3K9, is a representative histone methylation enzyme that induces the epigenetic silencing of tumor suppressor genes, including TP53, CDH1, DUSP5, and PTEN, contributing to cancer metastasis and the maintenance of the malignant phenotype80.