Our previous work showed that activation of the histone deacetylase SIRT1 by caloric restriction represses the development of arterial aneurysms, and SIRT1 activators have been tested for the potential to treat vascular diseases in animals and humans.23,43 More than ten SIRT6 activators (e.g., MDL-811) have been developed, some of which have been shown to significantly affect aging and stroke.44,45 Given the pivotal role of SIRT6 in aging and related vascular diseases, the potential of SIRT6 activators to treat TAA and other vascular diseases, such as atherosclerosis, should be explored. The gene discussed is SIRT1; the disease is stroke disorder.