Previous studies have revealed that inflammasomes and cleaved IL-1β contribute to the development of TAA and other vascular diseases, including atherosclerosis.24,27,32 Our findings identify SIRT6 as an epigenetic factor controlling IL-1β at the transcriptional level, enriching our understanding of IL-1β regulation and revealing an inflammasome-independent role for IL-1β in aging-related diseases such as TAA. The gene discussed is IL1B; the disease is atherosclerosis.