It could be hypothesized that chronic inflammation with auto-antibody production and T-cell mediated cytotoxic effect in HT, might result in DNA damage and genetic alterations [24]. We observed that 6 out of 12 cases of HT, had grooving, with 3 out of 6 cases being positive for RET/PTC gene translocation. The gene discussed is CCDC6; the disease is hematocrit.