Regarding the baseline values of different variables and literature review of previous studies, we selected some potential confounders and evaluated the insulin indices and diabetes incidence relationship using two adjusted models:1-age and sex adjusted model, 2- final model adjusted for BMI (only for food indices EDIR and EDIH), physical activity (only for EDIR and EDIH dietary indices), smoking, family history of diabetes, marital status, socioeconomic status, menopause status and daily energy intake. The gene discussed is INS; the disease is diabetes mellitus.