These indices consist of direct and indirect dietary and lifestyle components; the empirical indices for hyperinsulinaemia (EDIH and ELIH) can predict plasma C peptide as a long-term marker of endogenous insulin and the empirical indices for insulin resistance (EDIR and ELIR) based on increasing the triglyceride/ high-density lipoprotein-cholesterol (TG/HDL-c) ratio, they evaluate insulin resistance [12, 17]. The gene discussed is INS; the disease is Insulin resistance.