PBRM1 and clear cell renal carcinoma: For example, MCM8 and CCNA1, two cell cycle genes that are normally downregulated in clear cell renal carcinoma Caki-1/2 cells after exogenous PBRM1 expression (45), were significantly upregulated in PBRM1 knockdown cells that expressed PBRM1-BAHmut compared with PBRM1-BAHwt (Fig. 6D).