Prompted by this ambiguity, another research group reinvestigated the identity of the glioma CTX receptor and concluded that the direct binding partner protein comprising the CTX receptor is probably annexin A2 (ANX2) (10); although they admitted the possibility of other binding partners and did not verify the CTX–ANX2 interaction in a direct way using recombinantly produced and purified ANX2 protein. The gene discussed is ANXA2; the disease is central nervous system cancer.