In addition, of all the 31 Onco/TSGs harboured sHyperMethyl and sHypoMethyl in their gene body, 7 genes (HOXD11, TAL1, HOXA9, PAX5, FOXP1, FOXO1, TERT) were reported to serve as potential DNA methylation-based biomarkers for non-invasive early cancer diagnosis [46–54]. This evidence concerns the gene FOXO1 and cancer.