HAVCR2 and acute kidney injury: After cisplatin treatment, the body weight of WT mice and Tim-3 KO mice decreased by 19 and 25%, respectively (Fig. 1f); compared with WT mice, creatinine and BUN levels in the serum of Tim-3 KO mice were significantly increased by 2.59 times and 1.36 times, respectively (Fig. 1g, h), suggesting that Tim-3 can reduce the damage degree of renal function in cisplatin-induced AKI mice without influencing body weight.