HAVCR2 and acute kidney injury: After treatment with PDTC or TPCA1, serum creatinine in Tim-3 KO AKI mice were decreased by 80.2 and 40.8%, respectively (Fig. 4a); serum BUN in Tim-3 KO AKI mice was decreased by 85.0 and 58.8 %, respectively (Fig. 4b).