Previous studies had speculated that extracellular vesicles derived from platelets may facilitate the activation of I-κB and NF-κB pathways through CXCL7/CXCR2 axis in order to promote the tumor-associated biological changes of fibroblast-like synoviocytes in rheumatoid arthritis [67, 69]. The gene discussed is PPBP; the disease is neoplasm.