CXCR2 and neoplasm: In addition to the cancers mentioned above, CXC chemokines are also involved in the pathological mechanisms of prostate cancer, kidney renal clear cell carcinoma, melanoma, oral cancer, etc. For example, CXCL5 has autocrine and paracrine effects on malignant prostate cancer in prostate neoplasm cells and stroma which overexpress CXCL5, as well as participates in the regulation of tumor-related genes such as CXCR2, BAX, and ERK1/2 [59].