In the pathogenic mechanisms of diverse diseases, CXC chemokines usually play an essential role in regulating inflammation and immune responses through the migration of variety of leukocytes including neutrophils, monocytes, macrophages, etc. It affects tumor cells proliferation, invasion, metastasis, and angiogenesis via a variety of signaling pathways like STAT3 and NF-κB, thus accelerating the development of cancers. This evidence concerns the gene NFKB1 and cancer.