For example, several studies had reported that CXCL1, CXCL2 and CXCL8 are considered as participants and promoters in the occurrence of lung cancer by various mechanism, including recruiting neoplasm-associated neutrophils, participating in anlotinib resistance and influencing the proliferation of tumor cells and angiogenesis [20, 21]. This evidence concerns the gene CXCL8 and lung cancer.