Recently it has been confirmed that CXCLs control inflammation and immune responses through the migration of leukocytes including neutrophils, monocytes, macrophages, etc. They also regulate tumor cells proliferation, invasion, metastasis, and angiogenesis by activating different signaling pathways like STAT3 and NF-κB, thus accelerating the development of cancers. The gene discussed is NFKB1; the disease is neoplasm.