After a series of analysis they found that SLE mice exhibited remarkable renal chemotaxis and increased renal mRNA expression of CXC chemokines such as CXCL13 and CXCL16 compared to Non SLE mice, whereas EET analog therapy altered this situation so that the mRNA expression levels of CXC chemokines and its receptors as well as immunocytes infiltration associated with kidney was decreased [90]. This evidence concerns the gene CXCL13 and systemic lupus erythematosus.