Also, since CXCL8 played a significant role in stimulating tumor angiogenesis and promoting migration and invasion of tumor cells, Motyka et al. combined with CA15-3 to analyze the diagnostic utility of CXCL8 in BC and demonstrated that CXCL8 could be used as an extra diagnostic marker that had positive effect on the diagnostic utility of marker CA 15-3 [37]. This evidence concerns the gene CXCL8 and neoplasm.