ROCK2 and allergic asthma: By biochemical and genetic approaches, we have uncovered the protein SUMOylation in the regulation of goblet cell metaplasia in allergic airway epithelia and identified the ROCK2 SUMOylation on K1007 and subsequent its activation as a hitherto uncharacterized mechanism controlling goblet cell metaplasia and mucus hypersecretion that contribute to airway hyperreactivity in allergic asthma.