CBX4 and asthma: The present study is consistent with previous findings indicating that enrichment of the SUMOylation pathway represents a potential key regulator of airway remodeling23, and that SUMOylation is enhanced in the airway epithelia and inhibition of SUMOylation attenuates Th2 cell inflammation in allergen-induced mouse model of asthma, where chromobox 4 (CBX4), an E3 ligase, participates in the airway inflammation30,31.