Notably, the overall amount of p50 was similar in PHF6 KD myeloid leukemia cells and control cells in the presence or absence of TNFα, while the nuclear p50 and p65 significantly decreased after TNFα treatment in PHF6 KD Kasumi-1 and K562 cells when compared with the control cells respectively (Fig. 5B). Here, NFKB1 is linked to myeloid leukemia.