Additionally, the percentage of GFP+ c-Kit+ cells was significantly decreased, while the percentage of Mac-1+ cells was increased in the BM of VC Phf6,RE9a mice when compared with that of WT Phf6,RE9a mice (Fig. 2G), indicating that Phf6 KO promoted the differentiation of RE9a-induced leukemia cells. Here, PHF6 is linked to leukemia.