However, the sensitivity and specificity of current conventional biomarkers for LN disease activity and chronicity, such as proteinuria amount, urine sediments, serum creatinine value, titers of anti-double-stranded DNA (anti-dsDNA) antibodies, and serum C3 levels, are restricted [4] The most accurate method for diagnosing LN and assessing the severity of kidney injury is still invasive renal biopsy [1, 5]. Here, C3 is linked to lobular neoplasia.