LRRK2 and inflammatory bowel disease: Examples of this are the observations that LRRK2 expression and phosphorylation is upregulated in B-cells and microglia upon immune challenge and the identification of disease linked mutations for LRRK2 in Crohn’s disease24, a type of immune-mediated inflammatory bowel disease, as well as observations that pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes from the periphery to the brain25.