The irregulated circRNAs with strong m6A signatures were compared with the screening results of Fig. 3A section, and among these specific candidates, hsa-circ-0001451, which was formed by circularization of exon 3 and exon 4 of the FBXW7 gene, was chosen for its significant m6A difference and its potentially vital suppressive roles in cancer mediation we previously identified [15, 37]. Here, FBXW7 is linked to cancer.