Noteworthy, RMST restoration led also to a significant reduction in the expression of the stemness markers OCT4, SOX2 and NANOG. It is known from the literature that these three transcription factors play a key role in regulating the stem phenotype in several human cancers including TC [36, 37], and the observation that they are downregulated by RMST confirms the key role of the latter in repressing the stem characteristics of TC. Here, POU5F1 is linked to cancer.