Study of Eltro derivatives is required to obtain a better direct BAK activator to induce cancer cell death because: (1) the efficacy of Eltro in activating BAK and inducing cell death is much lower than BIM BH3 or BID BH3; and (2) Eltro directly induces BAK activation but inhibits BAX activation, whereas it might be possible to develop a BAK activator without the BAX inhibition properties. This evidence concerns the gene BAK1 and cancer.