Integration of the full-length CFTR cDNA and tCD19 enrichment cassette was confirmed into at least one allele per tCD19+ cell and the corrected airway basal stem cells were able to differentiate to produce epithelial sheets with restored CFTR-mediated chloride transport at an average of 70–80% of the levels seen for non-CF controls [60]. Here, CFTR is linked to cystic fibrosis.