In this narrative review, of all literature published through December 2022 was conducted using numerous primary topic headings combined with appropriate terms for each section of the article [e.g., pregnancy, preeclampsia, uteroplacental interface, estrogen, GPR30 or GPER, placentation, extravillous trophoblast, migration, invasion, endothelial dysfunction, oxidative stress, inflammation, hypoxia, angiogenesis]. This evidence concerns the gene GPER1 and preeclampsia.