They have shown that a low O2 tension upregulates HIF-1α which, in turn, increases the expression of GPER, and that these both molecules are recruited to the hypoxia-responsive element site located within the VEGF promoter region and cooperatively act as a functional complex for the transcription of VEGF and induction of tumor angiogenesis [127]. The gene discussed is GPER1; the disease is neoplasm.