As technology advances, new works have mapped the genetic and epigenomic characteristics of ESCC, including frequent high-level amplifications and homozygous deletions involving 11q13.2–q13.3 (locus of CCND1) and 9p21.3 (locus of CDKN2A and CDKN2B) [7]. Here, CDKN2B is linked to esophageal squamous cell carcinoma.