However, some HOX family genes were found to have high expression in the TCGA-ESCC-early cohort, but not in Chinese early ESCC samples, including HOXC6 (TCGA ESCC early, FC = 3.32; early ESCC, FC = 1.31), despite its reported role in ESCC progression. The gene discussed is HOXC6; the disease is esophageal squamous cell carcinoma.