8p11.23 commonly amplified in ESCC [25], and genes of this locus, such as BAG4 (fold change = 2.91, P value = 0.02), ZNF703 (fold change = 4.22, P value = 0.01) and F4EBP1 (fold change = 2.36, P value = 0.03), were identified as up-regulated genes in ESCC at mRNA level. Here, BAG4 is linked to esophageal squamous cell carcinoma.