Immunohistochemistry staining of HPA database showed that except CDKN3 was not found, AURKA, BIRC5, CCNB1, CDK1 and TYMS proteins were not or low expressed in normal liver tissues, while low (BIRC5), medium (CCNB1, CDK1 and TYMS) and high expression (AURKA) were shown in HBV-related HCC tissues (Fig. 2C). The gene discussed is TYMS; the disease is hepatocellular carcinoma.