CLU and ocular hypertension: This progressive dysfunction could be due to different reasons: precede the RGC death as suggested by animal models of ocular hypertension [86]; relate to the APOJ absence, which was recently identified as an astrocyte-secreted factor facilitating synapse formation and excitatory (glutamergic) synaptic transmission in the brain [87]; or reflect other, yet to identified, changes in the Apoj−/− retina.