It has been confirmed that radiotherapy may regulate aspirin in tumor cells by changing the activity of nuclear transcription factor (NF‐κB), while aspirin is an inhibitor of NF‐κB, and aspirin can induce apoptosis of cancer cells through NF‐κB activity in CRC and osteosarcoma.31, 32. Here, NFKB1 is linked to colorectal carcinoma.