ACSL4 and hepatocellular carcinoma: Taken together, these results strongly support the notion that SOR@TF-Fe3+ NVs are targeted initiators of HCC cell ferroptosis, given the enhanced presence of validated biomarkers (COX2, ACSL4, as well as Fe2+), the marked accumulation of lipid peroxides ROS and MDA products, evidence of mitochondrial membrane damage, and indeed eventual cell death except in the presence of ferroptotic inhibitors (ferrostatin 1).