Taken together, these results strongly support the notion that SOR@TF-Fe3+ NVs are targeted initiators of HCC cell ferroptosis, given the enhanced presence of validated biomarkers (COX2, ACSL4, as well as Fe2+), the marked accumulation of lipid peroxides ROS and MDA products, evidence of mitochondrial membrane damage, and indeed eventual cell death except in the presence of ferroptotic inhibitors (ferrostatin 1). This evidence concerns the gene PTGS2 and hepatocellular carcinoma.