SLC7A11 and hepatocellular carcinoma: For that reason, we performed a search of ferroptosis-related factors in the TCGA-LIHC project from the Cancer Genome Atlas (TCGA) database and found that TFRC, a ubiquitously expressed membrane protein, and SLC7A11 (subunit of antiporter system XC ̄) have significant upregulation (above other ferroptotic targets) in HCC cells when compared to normal tissue.