Meta-analysis determined that 15 CpG was interrelated with the plasma BPDE-Alb adducts, including Ubiquitin-conjugating enzyme E2 O (UBE2O), Sterile alpha motif domain containing protein 4A (SAMD4A), Acyl-CoA binding domain-containing 6 (ACBD6), Diacylglycerol kinase 2 (DGK2) and Schlafen 13 (SLFN13), which mediated the association between BaP exposure and 30%-60% lung cancer risk. This evidence concerns the gene SAMD4A and lung cancer.