Enhanced expression of miR503HG inhibit HCC invasion and metastasis.miR503HG interact with HNRNPA2B1 and promoted its degradation via the ubiquitin-proteasome pathway, which reduced the stability of p52 and p65 mRNA, and simultaneously suppressed the NF-κB signaling pathway in HCC cells. Here, HNRNPA2B1 is linked to hepatocellular carcinoma.