Oncometabolites, which mainly include 2-hydroxyglutarate, succinate and fumarate, refer to metabolites that drive distinct cancers and arise in human cancer due to somatic mutations in the isocitrate dehydrogenase (IDH) genes, fumarate hydratase (FH), or succinate dehydrogenase (SDH) gene [20]. The gene discussed is IDH3A; the disease is cancer.