Moreover, the top four significant genes, namely ADM (Cor = 0.276, p = 1.242e − 78), ENO1 (Cor = 0.229, p = 1.149e − 63), PLOD1 (Cor = 0.210, p = 6.321e − 58), and CEBPB (Cor = 0.210, p = 9.956e − 58) were considered as hub genes; the expression of these genes was strongly associated with DDIT4 expression in breast cancer. The gene discussed is ENO1; the disease is breast carcinoma.