Recently, a large number of studies have shown that PRIMPOL plays a key role in DNA replication, and changes in PRIMPOL activity may promote tumor formation [9, 11].For example, Quinet et al. found that in ovarian cancer cell UW, PRIMPOL depletion affects cell proliferation and cell viability in BRCA1-deficient cells [12]. Here, PRIMPOL is linked to ovarian cancer.