As expected, the putative targets of HuR involved in multiple pathways such as the inflammatory process, promotion of cell proliferation, EMT, matrix remodeling and tissue fibrosis that have been identified in cancer traits and CKD [28, 39] are also upregulated in IR-injured kidneys but markedly ameliorated when the interaction of HuR-mRNA of HuR targets is specifically inhibited by KH3. The gene discussed is ELAVL1; the disease is cancer.