ELAVL1 and chronic kidney disease: The present study further demonstrates that HuR significantly increases at the site of tubular injury both in progressive CKD in patients and in IR-injured kidneys in mice, accompanied by upregulation of HuR targets that are involved in inflammation, profibrotic cytokines, oxidative stress, proliferation, apoptosis, tubular EMT process and matrix remodeling in renal tubulointerstitial fibrosis.