Our report included three patients with AFP-producing gynecological malignant tumors: a 36-year-old female with endometrioid carcinoma and clear cell carcinoma (FIGO IVb), a 55-year-old postmenopausal woman with grade serous carcinoma (FIGO IIa), and a 60-year-old postmenopausal woman with high-grade epithelial carcinoma (FIGO Ic). The gene discussed is AFP; the disease is clear cell adenocarcinoma.