Our report included three patients with AFP-producing gynecological malignant tumors: a 36-year-old female with endometrioid carcinoma and clear cell carcinoma (FIGO IVb), a 55-year-old postmenopausal woman with grade serous carcinoma (FIGO IIa), and a 60-year-old postmenopausal woman with high-grade epithelial carcinoma (FIGO Ic). This evidence concerns the gene AFP and serous adenocarcinoma.