found that mutations of mitochondrial ferritin (FtMt) led to the dysfunction of FtMt in AMD patients (Stenirri et al. 2012), and its overexpression caused a decrease in mitochondrial membrane potential (MMP) and a reduction in OPA1, but promoted the fission of mitochondria (Wang et al. 2016b), suggesting that the overexpression of FtMt stimulated mitophagy to exert a protective effect in the RPE. Here, FTMT is linked to age-related macular degeneration.