NFE2L2 and age-related macular degeneration: Gurubaran et al. reported that a double knockout of NFE2L2/PGC-1α−/− resulted in an increased level of oxidative stress-related markers, the accumulation of damaged mitochondria, and the accumulation of lysosomal lipofuscin in the RPE in the mice, which is consistent with findings found in AMD patients (Gurubaran et al. 2020; Felszeghy et al. 2019; Kaarniranta et al. 2020).