In neurodegenerative diseases, sEVs orchestrate the mechanisms of secretion, transmission and degradation of miRNAs and misfolded proteins, i.e., Aβ, tau, α-Synuclein (α-Syn), mHtt, etc. In Parkinson’s disease (PD), pathologic α-Syn can be secreted via sEVs [8], spreading this protein to healthy neurons, astrocytes, and microglia which in turn may induce inflammatory reactions and cell death [9, 10]. This evidence concerns the gene MAPT and Parkinson disease.