Importantly, increases in COL8A1, BGN, COL11A1, POSTN, MMP11 and SORCS2 and decreased LTBP4, PCOLCE2, LRRC17 and SDK1 have been identified in CAS and CAFs from human breast cancer and are consistently perturbed in stroma of canine and human mammary cancer [11, 19, 20, 30, 38–42]. The gene discussed is PCOLCE2; the disease is breast cancer.