It did not squeeze out from the punctured hole nor dislocate in L5-L6 lumbar discs in the following 16 weeks in vivo experiments in the PGD and PGD + SDF-1α group, which avoided the failure of regeneration caused by lack of mechanical support and chemokine went out of NP and AF under compression. The gene discussed is CXCL12; the disease is atrial fibrillation.