The CD3+CD4+, CD3+CD8+ and NK cells in tumor from RNF8−/− mice were obviously lower than RNF8+/+ mice, LAC treatment significantly increased infiltration of CD3+CD4+, CD3+CD8+ and NK cells in tumors both in RNF8+/+ and RNF8−/− mice (Supplementary Fig. 5). Here, RNF8 is linked to neoplasm.