The three mechanisms by which greater overall adiposity may increase cancer risk have been extensively reported in the literature (sex hormone metabolism, insulin and insulin-like growth factors (IGF) signaling, and adipokine pathways) and could also explain some of the associations between longitudinal BMI-derived exposures and cancer risk (eg, corpus uteri, breast postmenopausal, colorectal cancers)14–21. Here, INS is linked to colorectal cancer.