BMP4 exerts an anti- inflammatory role and plays a critical role in the ISCs in the pathogenesis of IBD; Anti-BMP6 reagents attenuate intestinal inflammation in the DSS-induced colitis mice and correct the anaemia of IBD; BMP7 alleviates inflammation in TNBS-induced colitis and prevent intestinal fibrosis in the process of IBD. The gene discussed is BMP4; the disease is inflammatory bowel disease.