In a FLT3-ITD AML mouse model, animals treated with the MK8776 (CHK1 inhibitor) and cytarabine survived longer than those treated with cytarabine alone, suggesting that the combination of DNA damage response inhibitors and conventional chemotherapy may be useful in the treatment of FLT3-ITD AML [10]. This evidence concerns the gene CHEK1 and acute myeloid leukemia.