In this study, BLM aerosolization induced the production of pro-fibrotic and pro-inflammatory cytokines, mainly TGF-β1, TNF-α, IL-1β, and IL-6, and increased the expression of ECM proteins, such as α-SMA, collagen I, and fibronectin, in BLM-induced PF mice. The gene discussed is TNF; the disease is pemphigus foliaceus.