TSPYL2 and pemphigus foliaceus: Given the critical role of CDA1 in mediating the biological functions of TGF-β, this study explored the lung effects of targeted intervention with CDA1, with a particular focus on bleomycin (BLM)-induced pulmonary fibrosis (PF), ECM accumulation, lung fibroblast-to-myofibroblast transition, and TGF-β signal transduction.