LID + US also significantly increased the percentage of CD80 + DC in the tumor (Fig. 5g), increased the percentage of CD86 + DC in the tumor-draining lymph nodes (Fig. 5h), and enhanced the phosphorylation of TBK1 and IRF3, which were related to the activation of STING pathway in the tumor tissue (Fig. 5i). Here, IRF3 is linked to neoplasm.