We chose the FDA approved Indocyanine green (ICG) as the sonosensitizer28 and doxorubicin (DOX) as the chemotherapeutic for loading in liposomes to obtain liposomal ICG/DOX, denoted as LID, with an ultimate goal of unleashing the potential of tumor DNA for safe and effective STING activation and cancer immunotherapy (Fig. 1). Here, STING1 is linked to cancer.