For the distant MC38 tumor, LID + US + αPD-L1 enhanced the intratumoral CD8 + T cell infiltration by 37% and 70% compared with αPD-L1 (P < 0.01) and LID + US (P < 0.01), respectively, and the latter two groups failed to show any difference compared with the untreated control (Fig. 6h, i). The gene discussed is CD8A; the disease is neoplasm.