STING1 and neoplasm: We chose the FDA approved Indocyanine green (ICG) as the sonosensitizer28 and doxorubicin (DOX) as the chemotherapeutic for loading in liposomes to obtain liposomal ICG/DOX, denoted as LID, with an ultimate goal of unleashing the potential of tumor DNA for safe and effective STING activation and cancer immunotherapy (Fig. 1).