To explore the immune status of the infiltrated macrophages in GBM, we evaluated the differential expression of seven immunostimulatory GAM-related genes (TLR-4, IFNG, IL1B, TNF, NF2, CD80, and CD86) and seven immunosuppressive GAM-related genes (IDO, IL10, TGFB1, CCL2, CCL5, CD163, and MSR1) in patients with LGG and GBM and the relationships of these genes with survival in TCGA database (Fig. 1A, B). This evidence concerns the gene IL1B and glioblastoma.