LGALS9 and glioblastoma: Repolarizing M2-like GAMs into M1-like GAMs with effective biomaterials (such as a virus-mimicking membrane-coated nucleic acid nanogel Vir-Gel [47] and bovine serum albumin-MnO2-SAL [48]) or active molecules (such as Galectin-9 siRNA [49] and curcumin [50]) that were able to be transferred into the TIME and to exert therapeutic functions were considered a promising approach for GBM treatment.