IFNG and eye infection: For example, IFN-γ-producing invariant natural killer T (iNKT) cells alleviated the symptoms of ocular herpesvirus infection in mice [4], while IFN-γ gene knockout (KO) mice exhibited higher disease severity or virus reactivation rates after herpes simplex virus (HSV) type 1 infection as compared with wild-type mice [5, 6], which results suggest a protective role of IFN-γ in ocular infection.