Among the top 20 associated genes, the gene-set enrichment analysis showed that the GWAS catalog gene-set of Alzheimer’s disease or pleiotropy had 4 genes (GEMIN7, MARK4, PPP1R37, and NKPD1) overlapped (p = 1.74 × 10−7, adjusted-p = 3.16 × 10−4; Supplementary Table 5). The gene discussed is MARK4; the disease is early-onset autosomal dominant Alzheimer disease.