TGFB1 and open-angle glaucoma: TGF-β2 whose level is obviously elevated in the AH and TM tissue of primary open-angle glaucoma (POAG) patients is the most abundant TGF-β isoform in the eye and has been found to closely relate to the fibrotic pathogenesis in TM (Wang et al., 2017; Wordinger et al., 2014).