Parapuram et al. (2019) found that only AS605240, the inhibitor specific to certain PI3-kinase isoforms (p110γ), could effectively prevent TGF-β-induced collagen expression and PTEN phosphorylation in TM cells with less toxicity, and could be used as an anti-fibrotic agent targeting the TM tissue in glaucoma patients. This evidence concerns the gene TGFB1 and glaucoma.