TGFB2 and open-angle glaucoma: As shown by the results of small RNA sequencing, miR-486–5p was downregulated in POAG patients (Hubens et al., 2021), and transfection of miR-486–5p mimics in TM cells can significantly inhibit H2O2-stimulated ECM remodeling by blocking the TGF-β2/Smad2 signaling pathway (Xu et al., 2022).