IL6 and Anxiety: Acupuncture offers anti-inflammatory, anti-anxiety, antidepressive, gut flora improvement, and immune function regulation therapeutic benefits.[30] Compared with primary insomnia, the effect of electricity on secondary insomnia was more significant than in the control group.[28,31] Studies have indicated that in people with insomnia, inflammatory cytokines including IL-6 and TNF-α, as well as the gut flora, are more disrupted.