ACE2 and hypertensive disorder: COVID-19, which is caused by SARS-CoV-2, has raised public concern globally since it is characterized as a pandemic by the WHO.[12] Previous clinical and epidemiological data suggested that some comorbidities increase the SARS-CoV-2 infection risk with worse lung injury and death.[13] For example, in patients suffering from hypertension, angiotensin-converting enzyme 2 receptor is easier to have an upregulated expression due to the frequently using of angiotensin-converting enzyme 2 inhibitors and angiotensin receptor blockers.