UCHL1 and cancer: Besides its biological roles, UCH-L1 was suggested to be a crucial regulator of invasion and metastasis in various types of cancer including neuroblastoma,[4] pancreatic endocrine tumors,[5] and non-small cell lung cancer.[6] Previous studies showed the constitutive expression of UCH-L1 in human neural cell lines.[7] Studies of traumatic brain injury also showed that UCH-L1 expression was increased according to the severity of trauma and that it indicates a poor outcome.[8]