The autophagy-lysosome pathway and the ubiquitin-proteasome (UPS) pathway are 2 important pathways that control protein monitoring and degradation.[11] Deubiquitinating enzymes of the UPS are a novel concern for the development of new cancer therapeutics due to their frequent dysregulation in multiple cancer types.[11] The main subject of this study, UCH-L1, belongs to the family of deubiquitinating enzymes which remove ubiquitin from protein substrates.[11]. Here, UCHL1 is linked to cancer.